Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMO | Q99835 | 3/20 | 0.38 |
| ▸ | GHSR | Q92847 | 1/20 | 0.38 |
| ▸ | RBP4 | P02753 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3719845 | 1.00 | GAA (0.40) | GAAACHEHPGDL3MBTL1HTT | |
| SCHEMBL3718137 | 0.88 | GHSR (0.42) | GAAHPGDGHSRCYP3A4CYP2C9 | |
| SCHEMBL3714768 | 0.83 | MEN1 (0.40) | L3MBTL1HTTTSHRALDH1A1MAPT | |
| SCHEMBL3713712 | 0.82 | LIMK2 (0.42) | HPGDRBP4TSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL4970907 | 0.74 | DPP4 (0.31) | — | |
| SCHEMBL2904347 | 0.72 | — | — | |
| SCHEMBL19454030 | 0.70 | HPGD (0.64) | GAAACHEHPGDL3MBTL1SMO | |
| SCHEMBL252505 | 0.68 | ACHE (0.55) | GAAACHEHPGDL3MBTL1HTT | |
| SCHEMBL12812547 | 0.68 | HPGD (0.75) | GAAACHEHPGDL3MBTL1HTT | |
| SCHEMBL1429978 | 0.68 | PSEN1 (0.50) | ACHETSHRALDH1A1POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010102663-A1 | PIPERAZINE DERIVATIVES FOR USE IN THERAPY | GLAXO GROUP LIMITED (GB) | 2010-09-16 | — | — | WO | disclosed |