Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | CCKBR | P32239 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | RHOA | P61586 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | F10 | P00742 | 1/20 | 0.48 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2453924 | 0.93 | TRPV1 (0.53) | HTTKMT2AGAAALDH1A1HPGD | |
| SCHEMBL3443753 | 0.84 | PARP1 (0.62) | HTTSMN1; SMN2KMT2AGAAPOLB | |
| SCHEMBL3443750 | 0.84 | PARP1 (0.62) | HTTSMN1; SMN2KMT2AGAAPOLB | |
| SCHEMBL13106468 | 0.84 | PARP1 (0.62) | HTTSMN1; SMN2KMT2AGAAPOLB | |
| SCHEMBL21670300 | 0.82 | ALDH1A1 (0.47) | SMN1; SMN2GAAALDH1A1POLBRAB9A | |
| SCHEMBL21669960 | 0.82 | ALDH1A1 (0.47) | SMN1; SMN2GAAALDH1A1POLBRAB9A | |
| SCHEMBL3715390 | 0.81 | ABL1 (0.62) | HTTSMN1; SMN2KMT2AGAAALDH1A1 | |
| SCHEMBL5870918 | 0.81 | ABL1 (0.62) | HTTSMN1; SMN2KMT2AGAAALDH1A1 | |
| SCHEMBL486205 | 0.77 | KMT2A (0.65) | HTTSMN1; SMN2KMT2AGAAPOLB | |
| SCHEMBL259345 | 0.77 | PARP1 (0.62) | KMT2AGAAALDH1A1CCKBRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120854-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-10-21 | — | — | WO | disclosed |