Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 1/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | CDK9 | P50750 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 7/20 | 0.49 |
| ▸ | ITK | Q08881 | 2/20 | 0.47 |
| ▸ | JAK3 | P52333 | 3/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3714738 | 0.88 | EGFR (0.53) | EGFRITKJAK3MAPK8MAPK9 | |
| SCHEMBL3715520 | 0.88 | MAPK9 (0.43) | CCNT1CCNE1CDK2CDK9EGFR | |
| SCHEMBL3712392 | 0.87 | MAPK8 (0.45) | EGFRITKJAK3MAPK8MAPK9 | |
| SCHEMBL3723340 | 0.83 | MAPK8 (0.42) | EGFRITKJAK3MAPK8MAPK9 | |
| SCHEMBL3722239 | 0.83 | ULK1 (0.50) | CDK2EGFRITKJAK3BTK | |
| SCHEMBL3721800 | 0.82 | SYK (0.46) | CDK2EGFRITKJAK3MAPK8 | |
| SCHEMBL3714499 | 0.79 | MAPK9 (0.44) | EGFRITKMAPK8MAPK9SYK | |
| SCHEMBL914764 | 0.79 | STAT6 (0.60) | CCNT1CCNE1CDK2CDK9EGFR | |
| SCHEMBL3712502 | 0.79 | EGFR (0.44) | EGFRITKJAK3MAPK8MAPK9 | |
| SCHEMBL913674 | 0.77 | CCNT1 (0.55) | CCNT1CCNE1CDK2CDK9EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129802-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | WO | disclosed |