Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | CASP1 | P29466 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | HBB | P68871 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3718746 | 0.82 | MAPT (0.35) | MAPTMEN1KMT2AALDH1A1GAA | |
| SCHEMBL3722112 | 0.73 | MAPT (0.43) | MAPTMEN1KMT2AALDH1A1GAA | |
| SCHEMBL3722997 | 0.69 | FFAR1 (0.50) | — | |
| SCHEMBL10291561 | 0.68 | FFAR1 (0.43) | MAPTMEN1KMT2AALDH1A1GAA | |
| SCHEMBL1708367 | 0.68 | ALDH1A1 (0.36) | MAPTMEN1KMT2AALDH1A1GAA | |
| SCHEMBL3794315 | 0.65 | NPC1 (0.34) | MAPTALDH1A1GAASMN1; SMN2LMNA | |
| SCHEMBL287086 | 0.57 | PDCD1 (0.39) | — | |
| SCHEMBL21650283 | 0.57 | ALDH1A1 (0.37) | ALDH1A1CASP7HSD17B10 | |
| SCHEMBL6483853 | 0.57 | MAPT (0.51) | MAPTMEN1KMT2AALDH1A1GAA | |
| SCHEMBL5713734 | 0.55 | TUBB4A (0.64) | MAPTMEN1KMT2AALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010143733-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |