Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 2/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.50 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3715878 | 1.00 | MAOA (0.52) | MAOAHTR2ATRPA1GRIK1SMN1; SMN2 | |
| SCHEMBL11120194 | 0.92 | TRPA1 (0.59) | MAOAHTR2ATRPA1MAOBTRPV1 | |
| SCHEMBL5678156 | 0.88 | HTR2A (0.50) | MAOAHTR2ASMN1; SMN2CYP2A6TAAR1 | |
| SCHEMBL8787515 | 0.88 | HTR2A (0.50) | MAOAHTR2ASMN1; SMN2CYP2A6TAAR1 | |
| SCHEMBL456443 | 0.88 | HTR2A (0.50) | MAOAHTR2ASMN1; SMN2CYP2A6TAAR1 | |
| SCHEMBL5833581 | 0.87 | TRPA1 (0.56) | MAOAHTR2ATRPA1GRIK1SMN1; SMN2 | |
| SCHEMBL6677440 | 0.86 | MAOA (0.55) | MAOAHTR2ATRPA1GRIK1SMN1; SMN2 | |
| SCHEMBL2921490 | 0.83 | TRPA1 (0.53) | MAOATRPA1GRIK1SMN1; SMN2TRPV1 | |
| Hydrochloric Acid SCHEMBL8852295 | 0.82 | TRPA1 (0.51) | TRPA1GRIK1SMN1; SMN2MAOBTRPV1 | |
| SCHEMBL11549188 | 0.82 | TRPA1 (0.51) | MAOATRPA1GRIK1SMN1; SMN2HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100311798-A1 | 2-AMINOOXAZOLINES AS TAAR1 LIGANDS | HOFFMANN-LA ROCHE, INC. | 2010-12-09 | — | — | US | disclosed |
| WO-2010139707-A1 | 2-AMINOOXAZOLINES AS TAAR1 LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-12-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100311798-A1 | 2-AMINOOXAZOLINES AS TAAR1 LIGANDS | TAAR1, TAAR5, NPY2R | MAOA 105/4885HTR2A 15/4885TRPA1 276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.