Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15994855 | 0.93 | SIRT6 (0.53) | SIRT6LMNAALDH1A1MAPTPARP1 | |
| SCHEMBL1781593 | 0.93 | SIRT6 (0.53) | SIRT6LMNAALDH1A1MAPTPARP1 | |
| SCHEMBL375364 | 0.87 | SIRT6 (0.57) | SIRT6LMNAALDH1A1MAPTCDK2 | |
| SCHEMBL29446151 | 0.87 | SIRT6 (0.57) | SIRT6LMNAALDH1A1MAPTCDK2 | |
| SCHEMBL375370 | 0.81 | SIRT6 (0.51) | SIRT6LMNAALDH1A1MAPTCDK2 | |
| SCHEMBL30043078 | 0.79 | ALDH1A1 (0.46) | SIRT6LMNAALDH1A1MAPTACACB | |
| SCHEMBL16701931 | 0.79 | SIRT6 (0.53) | SIRT6LMNAALDH1A1MAPTCHEK1 | |
| SCHEMBL26087309 | 0.77 | ALDH1A1 (0.51) | SIRT6LMNAALDH1A1MAPTMAPK1 | |
| SCHEMBL20632691 | 0.77 | PDE4B (0.49) | ALDH1A1 | |
| SCHEMBL22348729 | 0.76 | ALDH1A1 (0.45) | SIRT6LMNAALDH1A1MAPTPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212326-A1 | 2-ANILINOPURIN-8-ONES AS INHIBITORS OF TTK/MPS1 FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | AstraZeneca AB (SE) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009024824-A1 | 2-ANILINOPURIN-8-ONES AS INHIBITORS OF TTK/MPS1 FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |