Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | TTK | P33981 | 1/20 | 0.42 |
| ▸ | NEK2 | P51955 | 1/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL375364 | 1.00 | SIRT6 (0.57) | SIRT6ALDH1A1LMNAMAPTMAOA | |
| SCHEMBL15994855 | 0.94 | SIRT6 (0.53) | SIRT6ALDH1A1LMNAMAPTHTR6 | |
| SCHEMBL1781593 | 0.94 | SIRT6 (0.53) | SIRT6ALDH1A1LMNAMAPTHTR6 | |
| SCHEMBL375370 | 0.93 | SIRT6 (0.51) | SIRT6ALDH1A1LMNAMAPTMAOA | |
| SCHEMBL16701931 | 0.90 | SIRT6 (0.53) | SIRT6ALDH1A1LMNAMAPTTGFBR1 | |
| SCHEMBL3716253 | 0.87 | SIRT6 (0.47) | SIRT6ALDH1A1LMNAMAPTCDK2 | |
| SCHEMBL26087309 | 0.87 | ALDH1A1 (0.51) | SIRT6ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL956959 | 0.87 | MAOA (0.48) | SIRT6ALDH1A1LMNAMAPTMAOA | |
| SCHEMBL1782418 | 0.86 | MAPT (0.53) | SIRT6ALDH1A1LMNAMAPTMAOA | |
| SCHEMBL1115458 | 0.86 | SIRT6 (0.44) | SIRT6ALDH1A1LMNAMAPTMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114592061-A | Prognostic biomarkers for TTK inhibitor chemotherapy | 荷兰转化研究中心有限责任公司 | 2022-06-07 | — | — | CN | disclosed |
| CN-107567503-B | Prognostic biomarkers for TTK inhibitor chemotherapy | 荷兰转化研究中心有限责任公司 | 2022-03-22 | — | — | CN | disclosed |