Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | USP7 | Q93009 | 5/20 | 0.40 |
| ▸ | USP47 | Q96K76 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3717157 | 0.75 | USP7 (0.69) | TSHRMAPK1USP7USP47MAPT | |
| SCHEMBL2681764 | 0.75 | USP7 (0.60) | TSHRMAPK1USP7USP47NPC1 | |
| SCHEMBL3715170 | 0.75 | S1PR4 (0.45) | TSHRMAPK1USP7NPC1MAPT | |
| SCHEMBL3713750 | 0.73 | TSHR (0.42) | TSHRMAPK1USP7NPC1RAB9A | |
| SCHEMBL3712718 | 0.72 | KIF18A (0.41) | TSHRMAPK1USP7USP47L3MBTL1 | |
| SCHEMBL3715750 | 0.71 | USP7 (0.57) | USP7USP47L3MBTL1SMN1; SMN2POLB | |
| SCHEMBL3714951 | 0.71 | VCAM1 (0.38) | TSHRMAPK1USP7L3MBTL1MAPT | |
| SCHEMBL3719652 | 0.68 | USP7 (0.60) | USP7USP47RAB9AMAPTALDH1A1 | |
| SCHEMBL3712957 | 0.68 | USP7 (0.58) | USP7USP47PADI4 | |
| SCHEMBL3712491 | 0.67 | USP7 (0.56) | USP7USP47IDO1PDE7APDE7B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010114881-A1 | ANTI-NEOPLASTIC COMPOUNDS, COMPOSITIONS AND METHODS | PROGENRA INC. (US) | 2010-10-07 | — | — | WO | claimed |
| WO-2010114881-A1 | ANTI-NEOPLASTIC COMPOUNDS, COMPOSITIONS AND METHODS | PROGENRA INC. (US) | 2010-10-07 | — | — | WO | disclosed |