SCHEMBL3716443

SCHEMBL3716443

CSc1ccc2c(c1)CCN2c1ncnc(OC2CCN(C(=O)O)CC2)c1C

nearest known ligand 0.47

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 20/20 0.47
CYP2C9 P11712 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL761736 0.89 GPR119 (0.58) GPR119CYP2C9
SCHEMBL288620 0.79 GPR119 (0.56) GPR119CYP2C9
SCHEMBL288318 0.79 GPR119 (0.61) GPR119CYP2C9
SCHEMBL288068 0.78 GPR119 (0.47) GPR119CYP2C9
SCHEMBL1768124 0.76 GPR119 (0.43) GPR119CYP2C9
SCHEMBL3241881 0.75 GPR119 (0.46) GPR119CYP2C9
SCHEMBL3238901 0.75 GPR119 (0.72) GPR119CYP2C9
SCHEMBL288618 0.75 GPR119 (0.75) GPR119CYP2C9
SCHEMBL288249 0.74 GPR119 (0.57) GPR119CYP2C9
SCHEMBL1066161 0.74 GPR119 (0.58) GPR119CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010128425-A1 GPR 119 MODULATORS PFIZER INC. (US) 2010-11-11 WO disclosed
WO-2010128414-A1 GPR 119 MODULATORS PFIZER INC. (US) 2010-11-11 WO disclosed