SCHEMBL288068

SCHEMBL288068

Cc1c(OC2CCN(C(=O)O)CC2)ncnc1N1CCc2ncccc21

nearest known ligand 0.47

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 19/20 0.47
CYP2C9 P11712 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL755863 0.88 GPR119 (0.64) GPR119CYP2C9
SCHEMBL300080 0.86 GPR119 (0.36) GPR119CYP2C9
SCHEMBL757014 0.86 GPR119 (0.36) GPR119CYP2C9
SCHEMBL288868 0.86 GPR119 (0.42) GPR119CYP2C9
SCHEMBL3512362 0.86 GPR119 (0.36) GPR119CYP2C9
SCHEMBL290047 0.86 GPR119 (0.36) GPR119CYP2C9
SCHEMBL759512 0.83 GPR119 (0.50) GPR119
SCHEMBL3713591 0.78 GPR119 (0.49) GPR119
SCHEMBL3716443 0.78 GPR119 (0.47) GPR119CYP2C9
SCHEMBL759433 0.78 GPR119 (0.36) GPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2427450-A1 GPR 119 MODULATORS Pfizer Inc. (US) 2012-03-14 EP claimed
WO-2010128425-A1 GPR 119 MODULATORS PFIZER INC. (US) 2010-11-11 WO claimed