Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 6/20 | 0.36 |
| ▸ | FAAH | O00519 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3718248 | 0.80 | HSD11B1 (0.38) | FAAHKMT2AALDH1A1EPHX2L3MBTL1 | |
| SCHEMBL3718796 | 0.75 | CYP1A2 (0.42) | CTSSFAAHALDH1A1DPP4L3MBTL1 | |
| SCHEMBL3718974 | 0.74 | KMT2A (0.35) | FAAHKMT2AEPHX2 | |
| SCHEMBL695114 | 0.73 | CTSS (0.40) | CTSSCTSL | |
| SCHEMBL3716343 | 0.69 | CYP1A2 (0.39) | DPP4 | |
| SCHEMBL3721567 | 0.69 | CYP1A2 (0.39) | CTSSFAAHHTTDPP4 | |
| SCHEMBL3715962 | 0.68 | SLC1A3 (0.46) | CTSSFAAHALDH1A1DPP4L3MBTL1 | |
| SCHEMBL4740683 | 0.66 | CTSS (0.55) | CTSSKMT2AALDH1A1SMN1; SMN2HTT | |
| SCHEMBL694969 | 0.66 | CTSS (0.43) | CTSSFAAHALDH1A1L3MBTL1CTSL | |
| SCHEMBL15327130 | 0.66 | CTSS (0.43) | CTSSFAAHALDH1A1L3MBTL1CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010121918-A1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-10-28 | — | — | WO | disclosed |