Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.41 |
| ▸ | ITK | Q08881 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 2/20 | 0.40 |
| ▸ | MMP8 | P22894 | 2/20 | 0.40 |
| ▸ | MMP13 | P45452 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13187751 | 0.91 | MAPK14 (0.42) | SYK | |
| SCHEMBL3713800 | 0.88 | HDAC1 (0.44) | TLR7ITKMMP2MMP8MMP13 | |
| SCHEMBL3715177 | 0.86 | TLR7 (0.44) | TLR7ITKKMT2A | |
| SCHEMBL3716614 | 0.81 | HDAC1 (0.49) | MMP2MMP8MMP13 | |
| SCHEMBL3710611 | 0.81 | ACACB (0.47) | ITKSYK | |
| SCHEMBL13188373 | 0.79 | HDAC1 (0.46) | — | |
| SCHEMBL3709560 | 0.78 | KMO (0.50) | — | |
| SCHEMBL3713318 | 0.77 | KMT2A (0.46) | ITKKMT2A | |
| SCHEMBL13188620 | 0.76 | KMO (0.47) | — | |
| SCHEMBL3713497 | 0.76 | KDM4E (0.40) | ITKMMP2MMP8MMP13KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |