Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 9/20 | 0.44 |
| ▸ | HSD11B2 | P80365 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TFPI2 | P48307 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3725686 | 0.95 | HPGD (0.64) | HPGDALDH1A1TSHRLMNAHTT | |
| SCHEMBL2677816 | 0.81 | ALDH1A1 (0.76) | HPGDALDH1A1TSHRLMNAHTT | |
| SCHEMBL20521101 | 0.81 | HPGD (0.63) | HPGDALDH1A1TSHRLMNASMN1; SMN2 | |
| SCHEMBL2676701 | 0.81 | ALDH1A1 (0.76) | HPGDALDH1A1TSHRLMNAHTT | |
| SCHEMBL15322429 | 0.81 | HPGD (0.63) | HPGDALDH1A1TSHRLMNASMN1; SMN2 | |
| SCHEMBL28735731 | 0.81 | HPGD (0.63) | HPGDALDH1A1TSHRLMNASMN1; SMN2 | |
| SCHEMBL17255293 | 0.81 | TSHR (0.49) | HPGDALDH1A1TSHRLMNAHTT | |
| SCHEMBL26124277 | 0.80 | HPGD (0.68) | HPGDALDH1A1TSHRLMNAHTT | |
| SCHEMBL493733 | 0.80 | HPGD (0.61) | HPGDALDH1A1TSHRLMNAHTT | |
| SCHEMBL19971623 | 0.78 | TFPI2 (0.46) | HPGDALDH1A1TSHRLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010138589-A1 | BICYCLIC PYRIMIDINE PI3K INHIBITOR COMPOUNDS SELECTIVE FOR P110 DELTA, AND METHODS OF USE | GENENTECH, INC. (US) | 2010-12-02 | — | — | WO | disclosed |