Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.69 |
| ▸ | THRB | P10828 | 1/20 | 0.65 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.52 |
| ▸ | ITGA1 | P56199 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3724198 | 0.90 | THRB (0.79) | POLBTHRBPFKFB3MEN1KMT2A | |
| SCHEMBL894613 | 0.84 | POLB (0.82) | POLBTHRBPFKFB3MEN1KMT2A | |
| SCHEMBL400223 | 0.84 | THRB (0.83) | POLBTHRBPFKFB3MEN1KMT2A | |
| SCHEMBL788070 | 0.81 | PFKFB3 (0.83) | POLBTHRBPFKFB3MEN1KMT2A | |
| SCHEMBL11025715 | 0.79 | POLB (0.78) | POLBTHRBPFKFB3MEN1KMT2A | |
| SCHEMBL17331335 | 0.79 | POLB (0.78) | POLBPFKFB3MEN1KMT2AMAPT | |
| SCHEMBL2888070 | 0.79 | POLB (0.94) | POLBPFKFB3MEN1KMT2AMAPT | |
| SCHEMBL2241495 | 0.79 | ITGA1 (0.80) | POLBPFKFB3MEN1KMT2AMAPT | |
| SCHEMBL30209693 | 0.79 | POLB (0.94) | POLBPFKFB3MEN1KMT2AMAPT | |
| SCHEMBL3556551 | 0.79 | THRB (0.65) | POLBTHRBPFKFB3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010126922-A1 | BENZIMIDAZOLECARBOXAMIDES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-11-04 | — | — | WO | disclosed |
| WO-2010126922-A1 | BENZIMIDAZOLECARBOXAMIDES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-11-04 | — | — | WO | disclosed |