Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | GLA | P06280 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | GALR2 | O43603 | 1/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7800550 | 0.89 | HTT (0.57) | HCAR3HTTALDH1A1MAPTKMT2A | |
| SCHEMBL10790188 | 0.84 | HTT (0.68) | HTTALDH1A1MAPTKMT2AGAA | |
| SCHEMBL28041172 | 0.81 | ALDH1A1 (0.52) | HTTALDH1A1MAPTKMT2AGAA | |
| SCHEMBL2342996 | 0.81 | HTT (0.59) | HCAR3HTTALDH1A1MAPTKMT2A | |
| SCHEMBL2777885 | 0.77 | KMT2A (0.54) | HTTALDH1A1MAPTKMT2AGAA | |
| SCHEMBL4908494 | 0.77 | ALDH1A1 (0.54) | HTTALDH1A1MAPTKMT2AGAA | |
| SCHEMBL265658 | 0.76 | ALDH1A1 (0.49) | HCAR3HTTALDH1A1MAPTGLA | |
| SCHEMBL7805730 | 0.76 | HTT (0.78) | HCAR3HTTALDH1A1MAPTKMT2A | |
| SCHEMBL22535975 | 0.75 | CYP3A4 (0.55) | HTTALDH1A1MAPTKMT2APKM | |
| SCHEMBL11215556 | 0.75 | NPSR1 (0.62) | HTTALDH1A1MAPTKMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010126922-A1 | BENZIMIDAZOLECARBOXAMIDES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-11-04 | — | — | WO | disclosed |
| WO-2010126922-A1 | BENZIMIDAZOLECARBOXAMIDES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-11-04 | — | — | WO | disclosed |