Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TMPRSS4 | Q9NRS4 | 3/20 | 0.39 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.39 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | STK39 | Q9UEW8 | 1/20 | 0.37 |
| ▸ | BCL2L11 | O43521 | 1/20 | 0.37 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | NQO2 | P16083 | 1/20 | 0.37 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17730406 | 0.81 | KDM4E (0.44) | CES2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL27966822 | 0.81 | CES2 (0.52) | CES2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL2001354 | 0.77 | CES2 (0.55) | CES2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL115659 | 0.74 | ALDH1A1 (0.65) | CES2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL2960949 | 0.74 | ALDH1A1 (0.46) | CES2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL25085859 | 0.73 | LMNA (0.35) | CES2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL1447588 | 0.73 | KDM4E (0.53) | CES2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL1451777 | 0.73 | MAPT (0.57) | CES2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL29540816 | 0.73 | MAPT (0.57) | CES2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL2960943 | 0.73 | CES2 (0.52) | CES2KDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2393788-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | N.V. Organon (NL) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010089297-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | N.V. ORGANON (NL) | 2010-08-12 | — | — | WO | disclosed |