Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 5/20 | 0.53 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 5/20 | 0.44 |
| ▸ | HTR2C | P28335 | 5/20 | 0.44 |
| ▸ | HTR2B | P41595 | 4/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | MPI | P34949 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8529317 | 0.88 | NOTUM (0.53) | PNMTNOTUMHTR2AHTR2CHTR2B | |
| SCHEMBL9510659 | 0.81 | PNMT (0.42) | PNMTHTR2AHTR2CHTR2BADRA2A | |
| SCHEMBL22389359 | 0.81 | PNMT (0.39) | PNMTHTR2AHTR2CHTR2BADRA2A | |
| SCHEMBL10911499 | 0.81 | KDM4E (0.39) | PNMTHTR2AHTR2CHTR2BADRA2A | |
| SCHEMBL10913735 | 0.81 | HTR2C (0.47) | PNMTHTR2AHTR2CHTR2BMAPT | |
| SCHEMBL19511770 | 0.80 | SRC (0.46) | PNMTMAPTKDM4EMEN1ALDH1A1 | |
| SCHEMBL10911889 | 0.77 | AR (0.37) | PNMTHTR2AHTR2CHTR2BMAPT | |
| SCHEMBL10911422 | 0.77 | PNMT (0.39) | PNMTNOTUMHTR2AHTR2CHTR2B | |
| SCHEMBL12604283 | 0.77 | PNMT (0.36) | PNMTMAPTKDM4EMEN1ALDH1A1 | |
| SCHEMBL5759503 | 0.76 | SRC (0.49) | PNMTHTR2CHTR2BADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100280024-A1 | RENIN INHIBITORS | CADILA HEALTHCARE LIMITED (IN) | 2010-11-04 | — | — | US | disclosed |
| EP-2205559-A1 | RENIN INHIBITORS | Cadila Healthcare Limited (IN) | 2010-07-14 | — | — | EP | disclosed |
| WO-2009087649-A1 | RENIN INHIBITORS | CADILA HEALTHCARE LIMITED (IN) | 2009-07-16 | — | — | WO | disclosed |
| US-4623377-A | PREEMERGENCE | NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) | 1986-11-18 | — | — | US | disclosed |
| EP-0158954-A2 | Tetrahydroquinolin-1-yl carbonyl imidazole derivatives, their intermediates; process for their preparation and herbicides or fungicides for agriculture or horticulture | NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) | 1985-10-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100280024-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | PNMT 1409/4885NOTUM 1050/4885HTR2A 3646/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.