Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.41 |
| ▸ | AXL | P30530 | 2/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
| ▸ | GAK | O14976 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3711387 | 0.88 | AAK1 (0.45) | AAK1FFAR1NR4A2AXLGAK | |
| SCHEMBL3713123 | 0.87 | IKBKE (0.51) | AAK1FFAR1NR4A2AXLCFTR | |
| SCHEMBL13188484 | 0.86 | NR4A2 (0.54) | NR4A2AXLCFTRALDH1A1CYP19A1 | |
| SCHEMBL3715859 | 0.86 | AAK1 (0.44) | AAK1FFAR1NR4A2AXLGAK | |
| SCHEMBL3709369 | 0.85 | AAK1 (0.41) | AAK1FFAR1NR4A2AXLCFTR | |
| SCHEMBL3715758 | 0.84 | ALDH2 (0.43) | AAK1FFAR1NR4A2AXLGAK | |
| SCHEMBL3711332 | 0.81 | FFAR1 (0.40) | AAK1FFAR1NR4A2CFTRALDH1A1 | |
| SCHEMBL3716087 | 0.81 | MEN1 (0.43) | AAK1FFAR1NR4A2GAKALDH1A1 | |
| SCHEMBL3713658 | 0.80 | OPRK1 (0.40) | AAK1NR4A2 | |
| SCHEMBL3715549 | 0.80 | OPRK1 (0.44) | AAK1NR4A2ALDH1A1CYP11B2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |