Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 4/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.36 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.36 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 4/20 | 0.35 |
| ▸ | HTR2C | P28335 | 4/20 | 0.35 |
| ▸ | HTR2B | P41595 | 4/20 | 0.35 |
| ▸ | HTR7 | P34969 | 3/20 | 0.35 |
| ▸ | HTR5A | P47898 | 3/20 | 0.35 |
| ▸ | HTR6 | P50406 | 3/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3723167 | 0.82 | HSP90AA1 (0.47) | HSP90AA1HSP90AB1PDE2APDE10AMEN1 | |
| SCHEMBL19785375 | 0.78 | HSP90AA1 (0.56) | HSP90AA1HSP90AB1PDE2APDE10AMEN1 | |
| SCHEMBL31345281 | 0.78 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1PDE2APDE10AMEN1 | |
| SCHEMBL3717873 | 0.75 | MEN1 (0.36) | HSP90AA1HSP90AB1PDE2APDE10AMEN1 | |
| SCHEMBL31449884 | 0.74 | MEN1 (0.47) | HSP90AA1HSP90AB1PDE2APDE10AMEN1 | |
| SCHEMBL22949436 | 0.72 | GPR3 (0.46) | PDE2APDE10AMEN1ALOX15KMT2A | |
| SCHEMBL30905970 | 0.72 | CA12 (0.46) | HSP90AA1HSP90AB1MEN1KMT2ACYP1A2 | |
| SCHEMBL322093 | 0.72 | CA12 (0.46) | HSP90AA1HSP90AB1MEN1KMT2ACYP1A2 | |
| SCHEMBL24042747 | 0.71 | HTR7 (0.57) | HTR1AHTR2CHTR2BHTR7HTR5A | |
| SCHEMBL321710 | 0.71 | NPC1 (0.50) | HSP90AA1HSP90AB1PDE2APDE10AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010136778-A1 | DIBENZOTHIOPHENE DERIVATIVES AS DNA- PK INHIBITORS | KUDOS PHARMACEUTICALS LIMITED (GB) | 2010-12-02 | — | — | WO | disclosed |
| WO-2010136778-A1 | DIBENZOTHIOPHENE DERIVATIVES AS DNA- PK INHIBITORS | KUDOS PHARMACEUTICALS LIMITED (GB) | 2010-12-02 | — | — | WO | disclosed |