SCHEMBL3723167

SCHEMBL3723167

COc1ccc(Cl)c(-c2cccc(Br)c2N)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 2/20 0.47
HSP90AB1 P08238 2/20 0.47
CYP3A4 P08684 2/20 0.43
ALDH1A1 P00352 1/20 0.43
SCN10A Q9Y5Y9 3/20 0.40
SMN1; SMN2 Q16637 1/20 0.38
MEN1 O00255 3/20 0.38
KMT2A Q03164 3/20 0.38
ALOX15 P16050 1/20 0.38
NUDT1 P36639 1/20 0.38
KDM1A O60341 1/20 0.38
ADORA2A P29274 1/20 0.37
ADORA1 P30542 1/20 0.37
ENPP3 O14638 1/20 0.36
ENPP1 P22413 1/20 0.36
MAPT P10636 2/20 0.36
NPSR1 Q6W5P4 2/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2D6 P10635 1/20 0.36
CYP2C9 P11712 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3717610 0.82 HSP90AA1 (0.40) HSP90AA1HSP90AB1CYP3A4SCN10AMEN1
SCHEMBL30485666 0.79 CD274 (0.46) CYP3A4ALDH1A1SMN1; SMN2MEN1KMT2A
SCHEMBL19785375 0.78 HSP90AA1 (0.56) HSP90AA1HSP90AB1CYP3A4ALDH1A1SCN10A
SCHEMBL15751000 0.78 HSP90AA1 (0.51) HSP90AA1HSP90AB1CYP3A4ALDH1A1SCN10A
SCHEMBL3717873 0.75 MEN1 (0.36) HSP90AA1HSP90AB1CYP3A4ALDH1A1SCN10A
SCHEMBL31448463 0.75 DPP4 (0.44) HSP90AA1HSP90AB1ALDH1A1SMN1; SMN2KMT2A
SCHEMBL31449884 0.74 MEN1 (0.47) HSP90AA1HSP90AB1CYP3A4ALDH1A1MEN1
SCHEMBL29092217 0.73 HSP90AA1 (0.50) HSP90AA1HSP90AB1SCN10AKDM1ACCNE1
SCHEMBL22949436 0.72 GPR3 (0.46) CYP3A4ALDH1A1MEN1KMT2AALOX15
SCHEMBL322093 0.72 CA12 (0.46) HSP90AA1HSP90AB1ALDH1A1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010136778-A1 DIBENZOTHIOPHENE DERIVATIVES AS DNA- PK INHIBITORS KUDOS PHARMACEUTICALS LIMITED (GB) 2010-12-02 WO disclosed