SCHEMBL9722822

SCHEMBL9722822

CN(C)S(=O)(=O)c1ccc2nc(N)sc2c1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.69
HPGD P15428 3/20 0.69
HSD17B10 Q99714 3/20 0.69
LMNA P02545 2/20 0.69
KDM4E B2RXH2 2/20 0.69
KMT2A Q03164 2/20 0.69
PKM P14618 1/20 0.69
MAPT P10636 3/20 0.56
VDR P11473 1/20 0.56
GFER P55789 1/20 0.56
GPR55 Q9Y2T6 1/20 0.56
CYP2D6 P10635 1/20 0.56
SMN1; SMN2 Q16637 5/20 0.53
PI4KA P42356 3/20 0.53
PI4KB Q9UBF8 3/20 0.53
PIK3CD O00329 2/20 0.53
PIK3CB P42338 2/20 0.53
PIK3CG P48736 2/20 0.53
PIK3CA P42336 2/20 0.53
USP2 O75604 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11592496 0.87 ALDH1A1 (0.64) ALDH1A1HPGDHSD17B10LMNAKDM4E
SCHEMBL13188896 0.86 PI4KA (0.59) ALDH1A1HPGDHSD17B10LMNAKDM4E
SCHEMBL11588774 0.84 ALDH1A1 (0.64) ALDH1A1HPGDHSD17B10LMNAKDM4E
SCHEMBL3717838 0.83 PI4KA (0.76) ALDH1A1HPGDHSD17B10LMNAKDM4E
SCHEMBL610238 0.83 LMNA (0.54) ALDH1A1HPGDHSD17B10LMNAKDM4E
SCHEMBL686784 0.83 ALDH1A1 (0.76) ALDH1A1HPGDHSD17B10LMNAKDM4E
SCHEMBL8298594 0.82 ALDH1A1 (1.00) ALDH1A1HPGDHSD17B10LMNAKDM4E
SCHEMBL11592571 0.82 ALDH1A1 (0.61) ALDH1A1HPGDHSD17B10LMNAKDM4E
SCHEMBL22230068 0.82 KMT2A (0.51) ALDH1A1HPGDHSD17B10LMNAKDM4E
SCHEMBL11589956 0.82 ALDH1A1 (0.57) ALDH1A1HPGDHSD17B10LMNAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11654203-B2 Dual-targeted carbonic anhydrase ix complex and contrast agent thereof Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan, R.O.C (TW) 2023-05-23 US disclosed
US-20210154334-A1 DUAL-TARGETED CARBONIC ANHYDRASE IX COMPLEX AND CONTRAST AGENT THEREOF Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan, R.O.C (TW) 2021-05-27 US disclosed
WO-2020150473-A2 PCSK9 INHIBITORS AND METHODS OF USE THEREOF DOGMA THERAPEUTICS, INC. (US) 2020-07-23 WO disclosed
US-20200071316-A1 ACTIVATORS OF THE RETINOIC ACID INDUCIBLE GENE \"RIG-I\" PATHWAY AND METHODS OF USE THEREOF Kineta Immuno-Oncology LLC 2020-03-05 US disclosed
US-20200071316-A1 ACTIVATORS OF THE RETINOIC ACID INDUCIBLE GENE \"RIG-I\" PATHWAY AND METHODS OF USE THEREOF Kineta Immuno-Oncology LLC 2020-03-05 US disclosed
US-5120872-A Textile dyeing CIBA-GEIGY CORPORATION (US) 1992-06-09 US disclosed
US-4994563-A Dyeing, printing cellulose, silk, wool, synthetic polyamides; colorfastness CIBA-GEIGY CORPORATION (US) 1991-02-19 US disclosed
US-4179435-A SULPHONIC ACID-FREE CIBA-GEIGY CORPORATION (US) 1979-12-18 US disclosed
US-4115381-A FOR POLYESTER FIBERS CIBA-GEIGY CORPORATION (US) 1978-09-19 US disclosed
US-4060544-A COUPLERS GAF CORPORATION (US) 1977-11-29 US disclosed
US-4041024-A FOR POLYAMIDES AND POLYURETHANES BAYER AKTIENGESELLSCHAFT (DT) 1977-08-09 US disclosed
US-4039524-A Keto-amido containing phenylazo benzothiazole dyestuffs GAF CORPORATION (US) 1977-08-02 US disclosed
US-4039529-A Cycloaliphatic dicarbonyl containing azo dyestuffs CIBA-GEIGY AG (CH) 1977-08-02 US disclosed
US-4006127-A Cationic diazacyanine dyestuffs BAYER AKTIENGESELLSCHAFT (DT) 1977-02-01 US disclosed
US-3957752-A QUATERNIZED AZOANILINO TOLUENE SULFONAMIDOALKYLENE-AMINE DYES AMERICAN ANILINE PRODUCTS, INC. (US) 1976-05-18 US disclosed
US-3950130-A THIAZOLE-AZO DYES AND THE COLORATION OF POLYESTER TEXTILE FIBERS THEREWITH AMERICAN ANILINE PRODUCTS, INC. (US) 1976-04-13 US disclosed
US-3931145-A POLYESTER GAF CORPORATION (US) 1976-01-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200071316-A1 ACTIVATORS OF THE RETINOIC ACID INDUCIBLE GENE \"RIG-I\" PATHWAY AND METHODS OF USE THEREOF RARB, RARG, RARA ALDH1A1 72/4885HPGD 1372/4885HSD17B10 983/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.