Ammonia Solution, Strong

Ammonia Solution, Strong

SCHEMBL3717839

CCC(N)c1ccncn1.N

nearest known ligand 0.40

Full drug profile on Sugi Atlas →

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.39
P2RX7 Q99572 1/20 0.34
CYP2D6 P10635 1/20 0.33
SLC6A4 P31645 1/20 0.32
CYP19A1 P11511 1/20 0.32
ALDH1A1 P00352 2/20 0.31
MEN1 O00255 1/20 0.31
POLB P06746 1/20 0.31
KMT2A Q03164 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
SCN1A P35498 1/20 0.30
SCN5A Q14524 1/20 0.30
SCN8A Q9UQD0 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2894352 0.98 HSP90AA1 (0.40) HSP90AA1P2RX7CYP2D6SLC6A4CYP19A1
SCHEMBL11813334 0.80 CYP2D6 (0.41) HSP90AA1P2RX7CYP2D6CYP19A1ALDH1A1
SCHEMBL3717840 0.78 HSP90AA1 (0.40) HSP90AA1P2RX7CYP19A1
SCHEMBL5669611 0.78 P2RX7 (0.43) HSP90AA1P2RX7CYP19A1
SCHEMBL10042014 0.78 HSP90AA1 (0.38) HSP90AA1P2RX7CYP2D6CYP19A1ALDH1A1
SCHEMBL24554448 0.76 HSP90AA1 (0.37) HSP90AA1P2RX7CYP2D6CYP19A1ALDH1A1
SCHEMBL12059428 0.76 HSP90AA1 (0.37) HSP90AA1P2RX7CYP2D6CYP19A1ALDH1A1
SCHEMBL1890998 0.76 HSP90AA1 (0.37) HSP90AA1P2RX7CYP2D6CYP19A1ALDH1A1
SCHEMBL13104790 0.76 HSP90AA1 (0.37) HSP90AA1P2RX7CYP2D6CYP19A1ALDH1A1
SCHEMBL26695870 0.76 HSP90AA1 (0.38) HSP90AA1P2RX7CYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010131145-A1 CYCLOBUTENEDIONE DERIVATIVES PFIZER LIMITED (GB) 2010-11-18 WO disclosed
WO-2010131146-A1 CYCLOBUTENEDIONE DERIVATIVES PFIZER LIMITED (GB) 2010-11-18 WO disclosed
WO-2010131147-A1 CYCLOBUTENEDIONE DERIVATIVES PFIZER LIMITED (GB) 2010-11-18 WO disclosed