SCHEMBL10042014

SCHEMBL10042014

CCC(CC)c1ccncn1

nearest known ligand 0.38

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.38
ESR1 P03372 1/20 0.36
ESR2 Q92731 1/20 0.36
CYP2D6 P10635 1/20 0.36
P2RX7 Q99572 1/20 0.33
TSHR P16473 1/20 0.33
CYP19A1 P11511 1/20 0.31
ALDH1A1 P00352 2/20 0.30
FAAH O00519 1/20 0.30
MEN1 O00255 1/20 0.30
POLB P06746 1/20 0.30
KMT2A Q03164 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16402489 0.88 ESR1 (0.36) HSP90AA1ESR1ESR2CYP2D6P2RX7
SCHEMBL13848633 0.88 CYP2D6 (0.36) HSP90AA1ESR1ESR2CYP2D6P2RX7
SCHEMBL26774452 0.85 CYP2D6 (0.41) HSP90AA1ESR1ESR2CYP2D6TSHR
SCHEMBL16919622 0.83 CYP2D6 (0.38) HSP90AA1ESR1ESR2CYP2D6P2RX7
SCHEMBL22308557 0.82 NR1I2 (0.40) CYP2D6TSHRALDH1A1FAAH
SCHEMBL26078439 0.82 NR1I2 (0.40) CYP2D6TSHRALDH1A1FAAH
SCHEMBL24554448 0.81 HSP90AA1 (0.37) HSP90AA1CYP2D6P2RX7TSHRCYP19A1
SCHEMBL1890998 0.81 HSP90AA1 (0.37) HSP90AA1CYP2D6P2RX7TSHRCYP19A1
SCHEMBL12059428 0.81 HSP90AA1 (0.37) HSP90AA1CYP2D6P2RX7TSHRCYP19A1
SCHEMBL13104790 0.81 HSP90AA1 (0.37) HSP90AA1CYP2D6P2RX7TSHRCYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230339907-A1 PROCESS FOR THE PREPARATION OF QUATERNIZED PYRIDAZINE DERIVATIVES SYNGENTA CROP PROTECTION AG (CH) 2023-10-26 US disclosed
US-20230303566-A1 INHIBITORS OF RAF KINASES Pierre Fabre Médicament (FR) 2023-09-28 US disclosed
US-20160008339-A1 PSORALEN DERIVATIVES FOR PREVENTING OR TREATING HEART FAILURE OR CARDIAC HYPERTROPHY MAX-DELBRUCK-CENTRUM FUR MOLEKULARE MEDIZIN (DE) 2016-01-14 US disclosed
US-8399458-B2 Compounds useful as protein kinase inhibitors VERTEX PHARMACEUTICALS INCORPORATED (US) 2013-03-19 US disclosed
US-8399458-B2 Compounds useful as protein kinase inhibitors VERTEX PHARMACEUTICALS INCORPORATED (US) 2013-03-19 US disclosed
US-20120028965-A1 COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS VERTEX PHARMACEUTICALS INCORPORATED (US) 2012-02-02 US disclosed
US-20120028965-A1 COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS VERTEX PHARMACEUTICALS INCORPORATED (US) 2012-02-02 US disclosed
US-7838517-B2 Compounds useful as protein kinase inhibitors VERTEX PHARMACEUTICALS INCORPORATED (US) 2010-11-23 US disclosed
US-7838517-B2 Compounds useful as protein kinase inhibitors VERTEX PHARMACEUTICALS INCORPORATED (US) 2010-11-23 US disclosed
US-20100286390-A1 PYRIDAZINONE COMPOUNDS AND P2X7 RECEPTOR INHIBITORS NISSAN CHEMICAL INDUSTRIES LIMITED 2010-11-11 US disclosed
US-7662971-B2 enzyme inhibitor for treating sleep disorders THE SCRIPPS RESEARCH INSTITUTE (US) 2010-02-16 US disclosed
US-20090281082-A1 COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS VERTEX PHARMACEUTICALS INCORPORATED (US) 2009-11-12 US disclosed
US-20090281082-A1 COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS VERTEX PHARMACEUTICALS INCORPORATED (US) 2009-11-12 US disclosed
US-20090270421-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE THE SCRIPPS RESEARCH INSTITUTE (US) 2009-10-29 US disclosed
US-20080108658-A1 METHODS OF PROMOTING OSTEOGENESIS PROTTER ANDREW A 2008-05-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160008339-A1 PSORALEN DERIVATIVES FOR PREVENTING OR TREATING HEART FAILURE OR CARDIAC HYPERTROPHY PAH, P4HA1, NPR3 HSP90AA1 659/4885ESR1 1319/4885ESR2 1077/4885
US-20090281082-A1 COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS MAP3K20, MAP3K6, MAP3K1 HSP90AA1 969/4885ESR1 2824/4885ESR2 3533/4885
US-20120028965-A1 COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS MAP3K20, MAP3K6, MAP3K1 HSP90AA1 969/4885ESR1 2824/4885ESR2 3533/4885
US-20080108658-A1 METHODS OF PROMOTING OSTEOGENESIS MAPK1, BMP2, MAPK3 HSP90AA1 1845/4885ESR1 3443/4885ESR2 3729/4885
US-20230339907-A1 PROCESS FOR THE PREPARATION OF QUATERNIZED PYRIDAZINE DERIVATIVES DHPS, PDXK, NQO1 HSP90AA1 4562/4885ESR1 4091/4885ESR2 4481/4885
US-20230303566-A1 INHIBITORS OF RAF KINASES BRAF, RAF1, ARAF HSP90AA1 855/4885ESR1 2072/4885ESR2 1735/4885
US-20100286390-A1 PYRIDAZINONE COMPOUNDS AND P2X7 RECEPTOR INHIBITORS P2RY1, P2RX7, P2RX1 HSP90AA1 3499/4885ESR1 1268/4885ESR2 1283/4885
US-20090270421-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE FAAH, FAAH2, CNR2 HSP90AA1 3021/4885ESR1 1474/4885ESR2 1102/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.