Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 10/20 | 0.67 |
| ▸ | CCR9 | P51686 | 2/20 | 0.53 |
| ▸ | PPARG | P37231 | 5/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.51 |
| ▸ | ECE1 | P42892 | 1/20 | 0.51 |
| ▸ | F10 | P00742 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL974474 | 0.87 | CCR2 (0.69) | CCR2PPARGABCB11F10 | |
| SCHEMBL1054163 | 0.87 | NOD2 (0.55) | CCR2PPARGECE1F10 | |
| SCHEMBL6300900 | 0.85 | CCR2 (0.65) | CCR2ECE1F10 | |
| SCHEMBL4206942 | 0.85 | CCR2 (0.68) | CCR2CCR9ABCB11 | |
| SCHEMBL4655319 | 0.84 | CCR2 (0.67) | CCR2CCR9PPARG | |
| SCHEMBL3191922 | 0.83 | CCR2 (0.76) | CCR2CCR9ABCB11 | |
| SCHEMBL3198946 | 0.83 | CCR2 (0.71) | CCR2CCR9PPARGABCB11 | |
| SCHEMBL6300893 | 0.83 | CCR2 (0.63) | CCR2CCR9PPARGABCB11F10 | |
| SCHEMBL6599972 | 0.83 | PPARG (0.68) | CCR2CCR9PPARGABCB11F10 | |
| SCHEMBL3664017 | 0.83 | CCR2 (0.55) | CCR2ABCB11ECE1F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2235014-B1 | BICYCLIC DERIVATIVES OF AZABICYCLIC CARBOXAMIDES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2013-10-09 | — | — | EP | disclosed |
| EP-2235014-A2 | BICYCLIC DERIVATIVES OF AZABICYCLIC CARBOXAMIDES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009112677-A2 | BICYCLIC DERIVATIVES OF AZABICYCLIC CARBOXAMIDES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2009-09-17 | — | — | WO | disclosed |