Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 5/20 | 0.42 |
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3467724 | 0.82 | CYP11B1 (0.47) | KDM4EALDH1A1HPGDL3MBTL1HTT | |
| SCHEMBL9021665 | 0.78 | KDM4E (0.61) | KDM4EALDH1A1HPGDL3MBTL1HTT | |
| SCHEMBL12855304 | 0.77 | ALDH1A1 (0.57) | KDM4EALDH1A1HPGDL3MBTL1HTT | |
| SCHEMBL3467721 | 0.76 | CASP1 (0.49) | KDM4EALDH1A1HPGDL3MBTL1HTT | |
| SCHEMBL13986853 | 0.76 | KDM4E (0.59) | KDM4EALDH1A1HPGDL3MBTL1HTT | |
| SCHEMBL8028548 | 0.75 | KDM4E (0.47) | KDM4EALDH1A1HPGDL3MBTL1HTT | |
| SCHEMBL17116615 | 0.75 | KDM4E (0.55) | KDM4EALDH1A1HPGDL3MBTL1HTT | |
| SCHEMBL25308859 | 0.75 | KDM4E (0.46) | KDM4EALDH1A1HPGDL3MBTL1HTT | |
| SCHEMBL19231297 | 0.75 | KDM1A (0.50) | KDM4EALDH1A1HPGDL3MBTL1HTT | |
| SCHEMBL9022425 | 0.75 | KDM4E (0.58) | KDM4EALDH1A1HPGDL3MBTL1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010085968-A1 | TOLUIDINE SULFONAMIDES AND THEIR USE AS HIF-INHIBITORS | EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) (DE) | 2010-08-05 | — | — | WO | disclosed |