Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | AR | P10275 | 4/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 3/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3997043 | 0.81 | MMP3 (0.46) | ALDH1A1ARGRIN1GRIN2B | |
| SCHEMBL8007166 | 0.78 | P2RX7 (0.44) | GRIN1GRIN2BP2RX7KDM1A | |
| SCHEMBL410177 | 0.77 | CYP2A6 (0.41) | ALDH1A1AR | |
| SCHEMBL8019866 | 0.76 | KDM4E (0.54) | KDM4EALDH1A1HPGDL3MBTL1HTT | |
| SCHEMBL29818872 | 0.76 | KDM4E (0.54) | KDM4EALDH1A1HPGDL3MBTL1HTT | |
| SCHEMBL8023947 | 0.76 | PTGER4 (0.48) | KDM4EALDH1A1P2RX7 | |
| SCHEMBL8028511 | 0.75 | HRH2 (0.42) | AREGLN2 | |
| SCHEMBL3467724 | 0.75 | CYP11B1 (0.47) | KDM4EALDH1A1HPGDL3MBTL1HTT | |
| SCHEMBL3718441 | 0.75 | KDM4E (0.47) | KDM4EALDH1A1HPGDL3MBTL1HTT | |
| SCHEMBL7941960 | 0.75 | P2RX7 (0.46) | KDM4EL3MBTL1GRIN1GRIN2BP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071504-A1 | 2,6-DISUBSTITUTED PYRIDINES AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-11 | — | — | WO | disclosed |