Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 10/20 | 0.44 |
| ▸ | ABL1 | P00519 | 2/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | BMX | P51813 | 3/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | STAT6 | P42226 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3715143 | 0.88 | MAP3K5 (0.51) | SYKABL1SRCJAK3MAPK8 | |
| SCHEMBL3716850 | 0.79 | CDK9 (0.49) | SYKLCKJAK3MAPK8MAPK9 | |
| SCHEMBL736146 | 0.77 | SYK (0.64) | SYK | |
| SCHEMBL914288 | 0.75 | STAT6 (0.63) | SYKJAK3STAT6 | |
| SCHEMBL913288 | 0.75 | MAPK8 (0.48) | SYKABL1SRCDDR1MAPK14 | |
| SCHEMBL3712339 | 0.75 | MAPK9 (0.42) | SYKJAK3MAPK8MAPK9STAT6 | |
| SCHEMBL913759 | 0.74 | MAP3K5 (0.52) | SYKABL1SRCLCKJAK3 | |
| SCHEMBL913568 | 0.74 | MAP3K5 (0.49) | SYKABL1SRCJAK3MAPK8 | |
| SCHEMBL3806715 | 0.72 | MAP3K5 (0.47) | SYKJAK3MAPK8MAPK9 | |
| SCHEMBL3806721 | 0.72 | MAP3K5 (0.47) | SYKJAK3MAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129802-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | WO | disclosed |