Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 3/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.49 |
| ▸ | CDK2 | P24941 | 2/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 7/20 | 0.46 |
| ▸ | JAK3 | P52333 | 4/20 | 0.43 |
| ▸ | SYK | P43405 | 6/20 | 0.42 |
| ▸ | BTK | Q06187 | 3/20 | 0.42 |
| ▸ | ITK | Q08881 | 2/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3715143 | 0.89 | MAP3K5 (0.51) | EGFRJAK3SYKBTKITK | |
| SCHEMBL3718752 | 0.79 | SYK (0.44) | JAK3SYKMAPK8MAPK9LCK | |
| SCHEMBL913759 | 0.77 | MAP3K5 (0.52) | EGFRJAK3SYKBTKITK | |
| SCHEMBL913808 | 0.77 | STAT6 (0.60) | CDK9CCNT1CDK2CCNE1EGFR | |
| SCHEMBL913568 | 0.77 | MAP3K5 (0.49) | EGFRJAK3SYKBTKITK | |
| SCHEMBL913156 | 0.76 | CDK9 (0.54) | CDK9CCNT1CDK2CCNE1EGFR | |
| SCHEMBL915078 | 0.75 | SYK (0.54) | EGFRJAK3SYKITKLCK | |
| SCHEMBL3720749 | 0.74 | CCNT1 (0.51) | CDK9CCNT1CDK2CCNE1EGFR | |
| SCHEMBL3714738 | 0.74 | EGFR (0.53) | EGFRJAK3SYKBTKITK | |
| SCHEMBL913817 | 0.74 | JAK3 (0.55) | EGFRJAK3SYKITKLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129802-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | WO | disclosed |