Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 10/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.37 |
| ▸ | ESRRA | P11474 | 1/20 | 0.37 |
| ▸ | AKT2 | P31751 | 1/20 | 0.37 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.37 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3725905 | 0.96 | P2RX7 (0.41) | P2RX7EPHX2ADORA2AKMT2AMAPK10 | |
| SCHEMBL3722862 | 0.90 | P2RX7 (0.43) | P2RX7EPHX2MAPK10MAPK8ESRRA | |
| SCHEMBL2549180 | 0.87 | L3MBTL1 (0.45) | P2RX7EPHX2PTPN7DUSP3 | |
| SCHEMBL13191685 | 0.87 | P2RX7 (0.39) | P2RX7EPHX2ADORA2AKMT2AMAPK10 | |
| SCHEMBL13191703 | 0.85 | P2RX7 (0.38) | P2RX7EPHX2ADORA2AKMT2A | |
| SCHEMBL13191622 | 0.85 | EPHX2 (0.47) | P2RX7EPHX2KMT2A | |
| SCHEMBL13191240 | 0.84 | EPHX2 (0.43) | P2RX7EPHX2KMT2A | |
| SCHEMBL13191684 | 0.84 | EPHX2 (0.39) | P2RX7EPHX2 | |
| SCHEMBL13191618 | 0.84 | EPHX2 (0.39) | P2RX7EPHX2 | |
| SCHEMBL13191624 | 0.84 | EPHX2 (0.40) | P2RX7EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010097373-A1 | COMPOUNDS FOR USE AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |