Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 2/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3719452 | 1.00 | SMN1; SMN2 (0.62) | SMN1; SMN2ALDH1A1NPC1HTTRAB9A | |
| SCHEMBL3719213 | 1.00 | SMN1; SMN2 (0.62) | SMN1; SMN2ALDH1A1NPC1HTTRAB9A | |
| SCHEMBL3716320 | 0.85 | ALDH1A1 (0.67) | SMN1; SMN2ALDH1A1NPC1HTTRAB9A | |
| SCHEMBL3723950 | 0.79 | LMNA (0.76) | SMN1; SMN2ALDH1A1NPC1HTTRAB9A | |
| SCHEMBL3725470 | 0.79 | ALDH1A1 (0.71) | SMN1; SMN2ALDH1A1NPC1HTTRAB9A | |
| SCHEMBL3798487 | 0.79 | ALDH1A1 (0.70) | SMN1; SMN2ALDH1A1NPC1HTTRAB9A | |
| SCHEMBL3717844 | 0.76 | ALDH1A1 (0.66) | SMN1; SMN2ALDH1A1NPC1HTTRAB9A | |
| SCHEMBL3723178 | 0.76 | ALDH1A1 (0.63) | SMN1; SMN2ALDH1A1NPC1HTTRAB9A | |
| SCHEMBL3719168 | 0.73 | ALDH1A1 (0.62) | SMN1; SMN2ALDH1A1NPC1HTTRAB9A | |
| SCHEMBL3720219 | 0.73 | ALDH1A1 (0.59) | SMN1; SMN2ALDH1A1NPC1HTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010134082-A1 | CHROMENONE DERIVATIVES FOR TREATMENT OF CANCER | PROTEOLOGICS LTD (IL) | 2010-11-25 | — | — | WO | disclosed |
| WO-2010134082-A1 | CHROMENONE DERIVATIVES FOR TREATMENT OF CANCER | PROTEOLOGICS LTD (IL) | 2010-11-25 | — | — | WO | disclosed |