Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | ESR1 | P03372 | 2/20 | 0.54 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3723178 | 0.92 | ALDH1A1 (0.63) | ALDH1A1SMN1; SMN2HTTNPC1RAB9A | |
| SCHEMBL3719248 | 0.84 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2HTTNPC1RAB9A | |
| SCHEMBL3725470 | 0.81 | ALDH1A1 (0.71) | ALDH1A1SMN1; SMN2HTTNPC1RAB9A | |
| SCHEMBL3719168 | 0.81 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2HTTNPC1RAB9A | |
| SCHEMBL3798487 | 0.79 | ALDH1A1 (0.70) | ALDH1A1SMN1; SMN2HTTNPC1RAB9A | |
| SCHEMBL3717844 | 0.78 | ALDH1A1 (0.66) | ALDH1A1SMN1; SMN2HTTNPC1RAB9A | |
| SCHEMBL3723950 | 0.77 | LMNA (0.76) | ALDH1A1SMN1; SMN2HTTNPC1RAB9A | |
| SCHEMBL3716178 | 0.74 | ALDH1A1 (0.61) | ALDH1A1SMN1; SMN2HTTNPC1RAB9A | |
| SCHEMBL3719213 | 0.73 | SMN1; SMN2 (0.62) | ALDH1A1SMN1; SMN2HTTNPC1RAB9A | |
| SCHEMBL3719210 | 0.73 | SMN1; SMN2 (0.62) | ALDH1A1SMN1; SMN2HTTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010134082-A1 | CHROMENONE DERIVATIVES FOR TREATMENT OF CANCER | PROTEOLOGICS LTD (IL) | 2010-11-25 | — | — | WO | disclosed |
| WO-2010134082-A1 | CHROMENONE DERIVATIVES FOR TREATMENT OF CANCER | PROTEOLOGICS LTD (IL) | 2010-11-25 | — | — | WO | disclosed |