Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 5/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.51 |
| ▸ | ACACB | O00763 | 2/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.41 |
| ▸ | GLI1 | P08151 | 1/20 | 0.39 |
| ▸ | GLI2 | P10070 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3722736 | 0.84 | TAAR1 (0.36) | SCN9A | |
| SCHEMBL3720675 | 0.84 | MTNR1A (0.50) | MTNR1AMTNR1BCES2SCN9ARAF1 | |
| SCHEMBL3718309 | 0.83 | MTNR1A (0.49) | MTNR1AMTNR1BCES2KDM4EALDH1A1 | |
| SCHEMBL3722768 | 0.82 | MTNR1A (0.50) | MTNR1AMTNR1BACACBSCN9ASMN1; SMN2 | |
| SCHEMBL3720171 | 0.82 | MTNR1A (0.57) | MTNR1AMTNR1BACACBSCN9ARAF1 | |
| SCHEMBL3723899 | 0.82 | KCNH3 (0.36) | SCN9AALDH1A1MAPT | |
| SCHEMBL3724455 | 0.81 | KCNH3 (0.37) | SCN9A | |
| SCHEMBL3727055 | 0.81 | ACACB (0.56) | MTNR1AMTNR1BACACBSCN9ASMN1; SMN2 | |
| SCHEMBL3723898 | 0.81 | PDE4B (0.50) | SMN1; SMN2LMNAMAPT | |
| SCHEMBL3726202 | 0.79 | ACACB (0.58) | MTNR1AMTNR1BACACBSCN9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127208-A1 | INHIBITORS OF ACETYL-COA CARBOXYLASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-11-04 | — | — | WO | disclosed |