SCHEMBL3719971

SCHEMBL3719971

O=C(O)NC1CC2(CCN(c3ccc(-c4ccc(F)cc4)cn3)CC2)C1

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
DGAT1 O75907 9/20 0.43
KCNH2 Q12809 6/20 0.43
ADORA2A P29274 1/20 0.43
RET P07949 2/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2C9 P11712 1/20 0.41
HTR1A P08908 1/20 0.41
DRD4 P21917 1/20 0.41
HTR2A P28223 1/20 0.41
SLC6A4 P31645 1/20 0.41
DRD3 P35462 1/20 0.41
CNR2 P34972 2/20 0.41
CNR1 P21554 1/20 0.41
TDO2 P48775 1/20 0.41
ACAT1 P24752 1/20 0.41
SCD O00767 1/20 0.39
HDAC3 O15379 1/20 0.39
HDAC2 Q92769 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15653977 0.94 DGAT1 (0.40) DGAT1KCNH2ADORA2ARETCYP3A4
SCHEMBL3723693 0.89 WNT3A (0.48) DGAT1KCNH2ADORA2ARETCYP3A4
SCHEMBL3722907 0.89 DGAT1 (0.40) DGAT1KCNH2ADORA2AHTR1ADRD4
SCHEMBL1729788 0.85 TDO2 (0.53) DGAT1KCNH2ADORA2ARETHTR1A
SCHEMBL15654738 0.85 FFAR4 (0.41) KCNH2CYP3A4CNR2CNR1HDAC2
Hydrochloric Acid SCHEMBL3724404 0.84 FFAR4 (0.40) KCNH2CYP3A4CNR2CNR1HDAC2
Hydrochloric Acid SCHEMBL3724408 0.83 FFAR4 (0.40) KCNH2RETCYP3A4CNR2CNR1
SCHEMBL3720052 0.82 DRD4 (0.44) DGAT1KCNH2ADORA2ARETCYP3A4
SCHEMBL15654957 0.82 DYRK1A (0.42) CNR2CNR1
SCHEMBL3723652 0.81 AKR1C3 (0.45) DGAT1KCNH2RETCYP3A4ACAT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2393809-B1 DERIVATIVES OF AZASPIRANYL-ALKYLCARBAMATES OF 5-MEMBER HETEROCYCLIC COMPOUNDS, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SANOFI SA (FR) 2014-04-30 EP claimed
EP-2393809-A2 DERIVATIVES OF AZASPIRANYL-ALKYLCARBAMATES OF 5-MEMBER HETEROCYCLIC COMPOUNDS, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SANOFI (FR) 2011-12-14 EP claimed
WO-2010089510-A2 DERIVATIVES OF AZASPIRANYL-ALKYLCARBAMATES OF 5-MEMBER HETEROCYCLIC COMPOUNDS, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2010-08-12 WO claimed
EP-2393809-B1 DERIVATIVES OF AZASPIRANYL-ALKYLCARBAMATES OF 5-MEMBER HETEROCYCLIC COMPOUNDS, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SANOFI SA (FR) 2014-04-30 EP disclosed
EP-2393809-A2 DERIVATIVES OF AZASPIRANYL-ALKYLCARBAMATES OF 5-MEMBER HETEROCYCLIC COMPOUNDS, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SANOFI (FR) 2011-12-14 EP disclosed
WO-2010089510-A2 DERIVATIVES OF AZASPIRANYL-ALKYLCARBAMATES OF 5-MEMBER HETEROCYCLIC COMPOUNDS, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2010-08-12 WO disclosed