Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.42 |
| ▸ | ACP1 | P24666 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | PTGFR | P43088 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3720119 | 0.83 | ACP1 (0.44) | KDM4ELMNAPIK3CAPIK3CBPIK3CG | |
| SCHEMBL3722028 | 0.81 | GRM2 (0.45) | SCN9AKDM4ELMNAHPGDGRM2 | |
| SCHEMBL3723259 | 0.78 | PTGS1 (0.48) | SCN9AKDM4EADORA1HPGDGRM2 | |
| SCHEMBL3720301 | 0.77 | KMT2A (0.43) | PIK3CAPIK3CBPIK3CGHPGDKMT2A | |
| SCHEMBL3718666 | 0.76 | KDM4E (0.55) | KDM4E | |
| SCHEMBL1734521 | 0.76 | HRH1 (0.52) | KDM4ELMNAPIK3CBADORA2AADORA1 | |
| SCHEMBL5089243 | 0.76 | MAPK8 (0.56) | PIK3CGCYP1A2 | |
| SCHEMBL3723027 | 0.74 | SCN9A (0.57) | SCN9AKDM4ELMNACYP3A4KMT2A | |
| SCHEMBL3727320 | 0.74 | SCN9A (0.43) | SCN9AKDM4ELMNAHPGDGRM2 | |
| SCHEMBL1734127 | 0.73 | KDM4E (0.57) | KDM4ELMNAADORA2AADORA1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | disclosed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | disclosed |