Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 19/20 | 0.52 |
| ▸ | CA2 | P00918 | 19/20 | 0.52 |
| ▸ | CA9 | Q16790 | 18/20 | 0.52 |
| ▸ | CA12 | O43570 | 9/20 | 0.51 |
| ▸ | CA14 | Q9ULX7 | 7/20 | 0.51 |
| ▸ | CA4 | P22748 | 4/20 | 0.51 |
| ▸ | CA6 | P23280 | 3/20 | 0.51 |
| ▸ | CA7 | P43166 | 3/20 | 0.51 |
| ▸ | CA3 | P07451 | 2/20 | 0.51 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.51 |
| ▸ | CA5A | P35218 | 2/20 | 0.49 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3717789 | 0.87 | SCN9A (0.53) | CA1CA2CA9CA12CA14 | |
| SCHEMBL3718669 | 0.83 | CA1 (0.54) | KDM4EPOLBCA1CA2CA9 | |
| SCHEMBL3722028 | 0.80 | GRM2 (0.45) | KDM4E | |
| SCHEMBL1734521 | 0.78 | HRH1 (0.52) | KDM4EPOLB | |
| SCHEMBL3723259 | 0.77 | PTGS1 (0.48) | KDM4ECA1CA2CA9 | |
| SCHEMBL3720301 | 0.76 | KMT2A (0.43) | — | |
| SCHEMBL3720116 | 0.76 | SCN9A (0.47) | KDM4E | |
| SCHEMBL3727320 | 0.74 | SCN9A (0.43) | KDM4E | |
| SCHEMBL3723027 | 0.72 | SCN9A (0.57) | KDM4E | |
| SCHEMBL3717779 | 0.71 | SCN9A (0.58) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | disclosed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | disclosed |