Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 3/20 | 0.43 |
| ▸ | FPR2 | P25090 | 1/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1734467 | 0.88 | KDM4E (0.53) | KDM4ECASP1LMNAALDH1A1HPGD | |
| SCHEMBL3722028 | 0.82 | GRM2 (0.45) | SCN9AFPR2GRM2MCL1KDM4E | |
| SCHEMBL3723259 | 0.82 | PTGS1 (0.48) | SCN9AFPR2GRM2MCL1KDM4E | |
| SCHEMBL3727322 | 0.79 | AGTR1 (0.43) | MCL1KDM4EAGTR1LMNAALDH1A1 | |
| SCHEMBL1734170 | 0.78 | VCP (0.51) | KDM4ELMNAALDH1A1HPGDGLA | |
| SCHEMBL3723027 | 0.76 | SCN9A (0.57) | SCN9AKDM4ELMNAALDH1A1GAA | |
| SCHEMBL3727139 | 0.75 | GRM2 (0.42) | SCN9AFPR2GRM2MCL1KDM4E | |
| SCHEMBL3720301 | 0.74 | KMT2A (0.43) | MCL1CASP1HPGD | |
| SCHEMBL3720116 | 0.74 | SCN9A (0.47) | SCN9AGRM2KDM4EAGTR1LMNA | |
| SCHEMBL3718666 | 0.74 | KDM4E (0.55) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | disclosed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | disclosed |