Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP1 | P24666 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | OGA | O60502 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3720116 | 0.83 | SCN9A (0.47) | ACP1PIK3CAPIK3CBPIK3CGAGTR1 | |
| SCHEMBL3719658 | 0.81 | DYRK1A (0.49) | PIK3CAPIK3CBPIK3CGKDM4EHPGD | |
| SCHEMBL3722029 | 0.79 | L3MBTL1 (0.44) | AGTR1CYP1A2SYKKDM4ELMNA | |
| SCHEMBL3723261 | 0.77 | PTGS1 (0.48) | AGTR1SYKKDM4ELMNAHPGD | |
| SCHEMBL3720305 | 0.76 | PIK3CA (0.43) | PIK3CAPIK3CBPIK3CGAGTR1IGF1R | |
| SCHEMBL3718669 | 0.75 | CA1 (0.54) | KDM4E | |
| SCHEMBL3727322 | 0.73 | AGTR1 (0.43) | PIK3CAPIK3CBPIK3CGAGTR1SYK | |
| SCHEMBL5089075 | 0.71 | OGA (0.53) | ACP1PIK3CAPIK3CBPIK3CGCYP1A2 | |
| SCHEMBL3717784 | 0.71 | ACP1 (0.47) | ACP1CYP1A2LMNAALDH1A1 | |
| SCHEMBL3727142 | 0.69 | AGTR1 (0.43) | AGTR1CYP1A2KDM4ELMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | disclosed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | disclosed |