Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9528926 | 0.83 | NOTUM (0.51) | NOTUMSMN1; SMN2MEN1KMT2ATSHR | |
| SCHEMBL14591324 | 0.83 | NOTUM (0.59) | NOTUMSMN1; SMN2MEN1KMT2ATSHR | |
| SCHEMBL17544697 | 0.83 | NOTUM (0.59) | NOTUMSMN1; SMN2MEN1KMT2ATSHR | |
| SCHEMBL29216428 | 0.81 | NOTUM (0.58) | NOTUMSMN1; SMN2MEN1KMT2ATSHR | |
| SCHEMBL19603153 | 0.80 | NOTUM (0.56) | NOTUMSMN1; SMN2MEN1KMT2ATSHR | |
| SCHEMBL9789155 | 0.79 | ALOX12 (0.64) | NOTUMSMN1; SMN2MEN1KMT2ATSHR | |
| SCHEMBL19447114 | 0.78 | NOTUM (0.55) | NOTUMSMN1; SMN2MEN1KMT2ATSHR | |
| SCHEMBL19603446 | 0.77 | NOTUM (0.52) | NOTUMSMN1; SMN2MEN1KMT2ATSHR | |
| SCHEMBL29216430 | 0.77 | NOTUM (0.52) | NOTUMSMN1; SMN2MEN1KMT2AATM | |
| SCHEMBL19601653 | 0.76 | NOTUM (0.51) | NOTUMSMN1; SMN2MEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2393812-B1 | SUBSTITUTED SPIROAMIDES AS B1R-MODULATORS | GRUENENTHAL GMBH (DE) | 2013-07-03 | — | — | EP | disclosed |
| EP-2393812-A1 | SUBSTITUTED SPIRO-AMIDES AS B1R MODULATORS | Grünenthal GmbH (DE) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010089127-A1 | SUBSTITUTED SPIRO-AMIDES AS B1R MODULATORS | Grünenthal GmbH (DE) | 2010-08-12 | — | — | WO | disclosed |