Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 4/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19603153 | 0.86 | NOTUM (0.56) | NOTUMTSHRALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL19603446 | 0.82 | NOTUM (0.52) | NOTUMTSHRALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL19601652 | 0.77 | GABRA1 (0.40) | TSHRALDH1A1MEN1KMT2AGABRA1 | |
| SCHEMBL17544697 | 0.77 | NOTUM (0.59) | NOTUMTSHRALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL14591324 | 0.77 | NOTUM (0.59) | NOTUMTSHRALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL19601646 | 0.76 | HRH3 (0.47) | ALDH1A1MEN1KMT2AGABRA1GABRB2 | |
| SCHEMBL19601639 | 0.76 | PIK3CD (0.42) | ALDH1A1MEN1KMT2AGABRA1GABRB2 | |
| SCHEMBL19601648 | 0.76 | RAB9A (0.38) | ALDH1A1SMN1; SMN2MEN1KMT2AGABRA1 | |
| SCHEMBL29216428 | 0.76 | NOTUM (0.58) | NOTUMTSHRALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL3720316 | 0.76 | NOTUM (0.58) | NOTUMTSHRALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10030020-B2 | Spirocycle compounds and methods of making and using same | ABIDE THERAPEUTICS, INC. (US) | 2018-07-24 | — | — | US | disclosed |
| US-10030020-B2 | Spirocycle compounds and methods of making and using same | ABIDE THERAPEUTICS, INC. (US) | 2018-07-24 | — | — | US | disclosed |
| US-20170327500-A1 | SPIROCYCLE COMPOUNDS AND METHODS OF MAKING AND USING SAME | H. LUNDBECK A/S (DK) | 2017-11-16 | — | — | US | disclosed |
| US-20170327500-A1 | SPIROCYCLE COMPOUNDS AND METHODS OF MAKING AND USING SAME | H. LUNDBECK A/S (DK) | 2017-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170327500-A1 | SPIROCYCLE COMPOUNDS AND METHODS OF MAKING AND USING SAME | ABHD6, ABHD16A, ACSL6 | NOTUM 710/4885TSHR 4623/4885ALDH1A1 932/4885 |
| US-10030020-B2 | Spirocycle compounds and methods of making and using same | ABHD6, ABHD16A, ACSL6 | NOTUM 710/4885TSHR 4623/4885ALDH1A1 932/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.