Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX12 | P18054 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3720316 | 0.79 | NOTUM (0.58) | ALOX12ALDH1A1NOTUMKDM4EHPGD | |
| SCHEMBL9789127 | 0.77 | ALOX12 (0.50) | ALOX12ALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL8554742 | 0.75 | ALOX12 (0.66) | ALOX12ALDH1A1CES1DRD2MEN1 | |
| SCHEMBL29785325 | 0.69 | ALOX12 (0.53) | ALOX12ALDH1A1KDM4EHPGDCES1 | |
| SCHEMBL28890266 | 0.69 | ALOX12 (0.53) | ALOX12ALDH1A1KDM4EHPGDCES1 | |
| SCHEMBL6643060 | 0.68 | NOTUM (0.44) | ALOX12ALDH1A1NOTUMCES1MEN1 | |
| SCHEMBL3396949 | 0.67 | ALDH1A1 (0.47) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL1437753 | 0.67 | ALDH1A1 (0.60) | ALOX12ALDH1A1NOTUMMEN1KMT2A | |
| SCHEMBL31359858 | 0.67 | BCL2L1 (0.52) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL29933410 | 0.67 | ALDH1A1 (0.60) | ALOX12ALDH1A1NOTUMMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4985424-A | Certain substituted 1,7-annelated 1h-indazoles being selective antagonists of 5-ht-receptors | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1991-01-15 | — | — | US | disclosed |
| US-4950759-A | ANTAGONISTS OF NEURONAL 5-HYDROXYTRYPTAMINE(5-HT) RECEPTORS | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1990-08-21 | — | — | US | disclosed |
| EP-0350130-A2 | New substituted 1,7-annelated 1H-indazoles | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1990-01-10 | — | — | EP | disclosed |