Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.74 |
| ▸ | RAB9A | P51151 | 2/20 | 0.74 |
| ▸ | PKM | P14618 | 2/20 | 0.74 |
| ▸ | NPC1 | O15118 | 1/20 | 0.74 |
| ▸ | CRHBP | P24387 | 1/20 | 0.74 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.74 |
| ▸ | HCAR3 | P49019 | 5/20 | 0.69 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3717593 | 0.90 | ALDH1A1 (0.60) | MAPTALDH1A1RAB9APKMNPC1 | |
| SCHEMBL2338538 | 0.90 | HCAR3 (0.67) | MAPTALDH1A1RAB9APKMNPC1 | |
| SCHEMBL5315342 | 0.87 | MAPT (0.81) | MAPTALDH1A1RAB9APKMNPC1 | |
| SCHEMBL2688335 | 0.82 | HCAR3 (1.00) | MAPTALDH1A1RAB9APKMNPC1 | |
| SCHEMBL2245654 | 0.81 | MAPT (0.56) | MAPTALDH1A1RAB9APKMNPC1 | |
| SCHEMBL17336716 | 0.81 | KMT2A (0.55) | MAPTALDH1A1RAB9APKMNPC1 | |
| SCHEMBL13077023 | 0.81 | HCAR3 (0.56) | MAPTALDH1A1RAB9APKMNPC1 | |
| SCHEMBL22118764 | 0.81 | HCAR3 (0.78) | MAPTALDH1A1RAB9APKMNPC1 | |
| SCHEMBL23417879 | 0.81 | MAPT (0.55) | MAPTALDH1A1RAB9APKMNPC1 | |
| SCHEMBL2248331 | 0.80 | MAPT (0.54) | MAPTALDH1A1RAB9APKMNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010126922-A1 | BENZIMIDAZOLECARBOXAMIDES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-11-04 | — | — | WO | disclosed |
| WO-2010126922-A1 | BENZIMIDAZOLECARBOXAMIDES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-11-04 | — | — | WO | disclosed |