Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | NCF1 | P14598 | 4/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.34 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NPY1R | P25929 | 1/20 | 0.33 |
| ▸ | NPY2R | P49146 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3721856 | 0.93 | MAPT (0.37) | MAPTLMNAMAPK1HIF1ATLR8 | |
| SCHEMBL3717500 | 0.91 | MAPT (0.39) | MAPTMAPK1NCF1KDM4EMEN1 | |
| SCHEMBL3720645 | 0.88 | MAPT (0.39) | MAPTLMNAMAPK1HIF1ANCF1 | |
| SCHEMBL3718572 | 0.87 | PNLIP (0.40) | MAPTLMNAMAPK1HIF1ANCF1 | |
| SCHEMBL3720292 | 0.85 | MAPT (0.41) | MAPTLMNAMAPK1HIF1ANCF1 | |
| SCHEMBL3718483 | 0.85 | MAPT (0.38) | MAPTLMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL3726082 | 0.85 | MAPT (0.37) | MAPTMAPK1HPSEKDM4EMEN1 | |
| SCHEMBL3719458 | 0.83 | PARP15 (0.37) | MAPT | |
| SCHEMBL3717278 | 0.82 | CSNK2A1 (0.39) | MAPTMAPK1TLR8KDM4EMEN1 | |
| SCHEMBL3718569 | 0.82 | MAPT (0.37) | MAPTLMNATLR8MEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127208-A1 | INHIBITORS OF ACETYL-COA CARBOXYLASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-11-04 | — | — | WO | disclosed |