Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | MMP8 | P22894 | 1/20 | 0.53 |
| ▸ | MMP12 | P39900 | 1/20 | 0.53 |
| ▸ | MMP13 | P45452 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CCR1 | P32246 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.45 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27708515 | 0.83 | CCR1 (0.41) | LMNAMMP8MMP12MMP13POLB | |
| SCHEMBL5242582 | 0.80 | AKR1C3 (0.58) | POLBHSD11B1CCR1L3MBTL1 | |
| SCHEMBL7359593 | 0.79 | MMP8 (0.55) | LMNAMMP8MMP12MMP13POLB | |
| SCHEMBL2706478 | 0.79 | TSHR (0.60) | MMP8MMP12MMP13POLBALDH1A1 | |
| SCHEMBL2706475 | 0.79 | TSHR (0.60) | MMP8MMP12MMP13POLBALDH1A1 | |
| SCHEMBL27932411 | 0.79 | POLB (0.58) | LMNAMMP8MMP12MMP13POLB | |
| SCHEMBL3722693 | 0.79 | POLB (0.58) | LMNAMMP8MMP12MMP13POLB | |
| SCHEMBL3727147 | 0.79 | MMP8 (0.58) | LMNAMMP8MMP12MMP13POLB | |
| SCHEMBL639239 | 0.78 | ATM (0.42) | LMNAHSD11B1ALDH1A1CCR1ATM | |
| SCHEMBL639240 | 0.78 | ATM (0.42) | LMNAHSD11B1ALDH1A1CCR1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | claimed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | claimed |
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | disclosed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | disclosed |