SCHEMBL3727147

SCHEMBL3727147

O=C(O)[C@@H]1CCCN1S(=O)(=O)c1ccccc1Cl

nearest known ligand 0.61

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MMP8 P22894 1/20 0.58
MMP12 P39900 1/20 0.58
MMP13 P45452 1/20 0.58
ALDH1A1 P00352 2/20 0.53
HTT P42858 2/20 0.53
HSD11B1 P28845 1/20 0.53
FAAH O00519 3/20 0.52
POLB P06746 1/20 0.51
KDM4E B2RXH2 2/20 0.49
TSHR P16473 1/20 0.49
CASP1 P29466 1/20 0.49
CASP7 P55210 1/20 0.49
LMNA P02545 1/20 0.47
MAPT P10636 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
HSD17B10 Q99714 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7359593 0.89 MMP8 (0.55) MMP8MMP12MMP13ALDH1A1HTT
SCHEMBL14530359 0.87 HSD11B1 (0.52) HSD11B1FAAHLMNAMAPTSMN1; SMN2
SCHEMBL10037186 0.85 HSD11B1 (0.53) HSD11B1FAAHTSHRLMNAMAPT
SCHEMBL9451843 0.83 ALDH1A1 (0.56) MMP8MMP12MMP13ALDH1A1HTT
SCHEMBL31717377 0.83 HTT (0.53) MMP8MMP12MMP13ALDH1A1HTT
SCHEMBL5062486 0.83 HTT (0.53) MMP8MMP12MMP13ALDH1A1HTT
SCHEMBL27932411 0.83 POLB (0.58) MMP8MMP12MMP13ALDH1A1HTT
SCHEMBL3722693 0.83 POLB (0.58) MMP8MMP12MMP13ALDH1A1HTT
SCHEMBL3720830 0.83 L3MBTL1 (0.60) MMP8MMP12MMP13ALDH1A1HTT
SCHEMBL3717614 0.81 MMP8 (0.53) MMP8MMP12MMP13ALDH1A1HSD11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8614201-B2 Heterocyclic amides as modulators of TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2013-12-24 US claimed
WO-2010141805-A1 HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2010-12-09 WO claimed
US-8614201-B2 Heterocyclic amides as modulators of TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2013-12-24 US disclosed
WO-2010141805-A1 HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2010-12-09 WO disclosed