Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 2/20 | 0.59 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.53 |
| ▸ | TGFBR2 | P37173 | 3/20 | 0.53 |
| ▸ | PRKCI | P41743 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3724250 | 0.82 | TGFBR1 (0.53) | METAP1TGFBR1TGFBR2PRKCIKDM4E | |
| SCHEMBL3799227 | 0.82 | TGFBR1 (0.53) | METAP1TGFBR1TGFBR2PRKCIKDM4E | |
| SCHEMBL2414768 | 0.78 | TGFBR1 (0.53) | TGFBR1TGFBR2PRKCIMETAP2AXL | |
| SCHEMBL2231632 | 0.78 | ADORA1 (0.51) | PRKCIL3MBTL1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL4473954 | 0.74 | METAP1 (1.00) | METAP1KDM4ETDP1L3MBTL1ALOX15 | |
| SCHEMBL3671378 | 0.74 | TGFBR1 (0.55) | TGFBR1TGFBR2PRKCIKDM4ETDP1 | |
| SCHEMBL7750000 | 0.73 | PIK3CA (0.41) | TGFBR1PRKCIKDM4ESMN1; SMN2HPGD | |
| SCHEMBL20665660 | 0.72 | KDM4E (0.63) | METAP1KDM4ETDP1L3MBTL1ALOX15 | |
| SCHEMBL2154969 | 0.72 | NUDT1 (0.52) | PRKCIKDM4EL3MBTL1ALOX15NPC1 | |
| SCHEMBL29354466 | 0.70 | KDM4E (1.00) | METAP1KDM4ETDP1L3MBTL1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8314112-B2 | Pyrrolopyrimidines and pyrrolopyridines | NOVARTIS AG (CH) | 2012-11-20 | — | — | US | disclosed |
| EP-2242756-A2 | PYRROLOPYRIMIDINES AND PYRROLOPYRIDINES | Novartis AG (CH) | 2010-10-27 | — | — | EP | disclosed |
| US-20090181941-A1 | Pyrrolopyrimidines and Pyrrolopyridines | NOVARTIS AG (CH) | 2009-07-16 | — | — | US | disclosed |
| WO-2009087225-A2 | PYRROLOPYRIMIDINES AND PYRROLOPYRIDINES | NOVARTIS AG (CH) | 2009-07-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181941-A1 | Pyrrolopyrimidines and Pyrrolopyridines | ALK, ACVR1, PTPN4 | METAP1 1915/4885TGFBR1 128/4885TGFBR2 443/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.