Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 5/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | PNMT | P11086 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14025213 | 0.81 | SMN1; SMN2 (0.54) | KCNH2SMN1; SMN2PTGS2 | |
| SCHEMBL3713194 | 0.80 | HTR2A (0.35) | SLC6A4SLC6A3KCNH2CACNA1BNR1I2 | |
| SCHEMBL23143746 | 0.80 | G6PD (0.49) | KCNH2TMEM97SIGMAR1SMN1; SMN2CACNA1B | |
| Hydrochloric Acid SCHEMBL4916424 | 0.80 | SMN1; SMN2 (0.53) | KCNH2SMN1; SMN2PTGS2 | |
| SCHEMBL18230961 | 0.78 | FFAR4 (0.43) | KCNH2TMEM97SIGMAR1SMN1; SMN2CACNA1B | |
| SCHEMBL3710331 | 0.76 | KIF11 (0.46) | KCNH2PTGS2NR1H2NR1H3HRH4 | |
| SCHEMBL18230946 | 0.76 | MAPT (0.44) | SLC6A4SLC6A3KCNH2TMEM97SIGMAR1 | |
| SCHEMBL24254583 | 0.76 | SMN1; SMN2 (0.45) | SLC6A4SLC6A3KCNH2TMEM97SIGMAR1 | |
| SCHEMBL23155765 | 0.74 | LRRK2 (0.46) | KCNH2TMEM97SIGMAR1SMN1; SMN2PTGS2 | |
| SCHEMBL3711714 | 0.74 | IDO1 (0.42) | SLC6A4SLC6A3KCNH2HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010096722-A1 | 3-OXO-2, 3-DIHYDRO- [1,2, 4] TRIAZOLO [4, 3-A]PYRIDINES AS SOLUBLE EPOXIDE HYDROLASE (SEH) INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-26 | — | — | WO | claimed |
| WO-2010096722-A1 | 3-OXO-2, 3-DIHYDRO- [1,2, 4] TRIAZOLO [4, 3-A]PYRIDINES AS SOLUBLE EPOXIDE HYDROLASE (SEH) INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-26 | — | — | WO | disclosed |