Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV3 | Q8NET8 | 9/20 | 0.54 |
| ▸ | SCN9A | Q15858 | 7/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15244774 | 0.85 | TRPV3 (0.53) | TRPV3SCN9AMAOB | |
| SCHEMBL2302878 | 0.84 | CTSS (0.56) | TRPV3MAOB | |
| SCHEMBL27371412 | 0.83 | TRPV3 (0.54) | TRPV3SCN9ALTA4HKIF11 | |
| SCHEMBL4592059 | 0.83 | TRPV3 (0.61) | TRPV3SCN9A | |
| SCHEMBL4831269 | 0.83 | TRPV3 (0.54) | TRPV3SCN9ALTA4HKIF11 | |
| SCHEMBL30755490 | 0.83 | TRPV3 (0.54) | TRPV3SCN9ALTA4HKIF11 | |
| SCHEMBL4592336 | 0.83 | TRPV3 (0.54) | TRPV3SCN9ALTA4HKIF11 | |
| SCHEMBL28199041 | 0.80 | HRH3 (0.50) | LTA4H | |
| SCHEMBL1239870 | 0.78 | MEN1 (0.60) | TRPV3 | |
| SCHEMBL10649352 | 0.77 | IRAK4 (0.42) | LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | claimed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | claimed |
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | disclosed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | disclosed |