SCHEMBL4831269

SCHEMBL4831269

FC(F)(F)c1ccc(-c2cccc(CBr)n2)cc1

nearest known ligand 0.54

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
TRPV3 Q8NET8 10/20 0.54
SCN9A Q15858 6/20 0.46
KIF11 P52732 2/20 0.41
LTA4H P09960 1/20 0.40
CHRNA7 P36544 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30755490 1.00 TRPV3 (0.54) TRPV3SCN9AKIF11LTA4HCHRNA7
SCHEMBL3721067 0.83 TRPV3 (0.54) TRPV3SCN9AKIF11LTA4H
SCHEMBL27371412 0.83 TRPV3 (0.54) TRPV3SCN9AKIF11LTA4H
SCHEMBL4592059 0.83 TRPV3 (0.61) TRPV3SCN9A
SCHEMBL4592336 0.83 TRPV3 (0.54) TRPV3SCN9AKIF11LTA4H
SCHEMBL4435179 0.78 MEN1 (0.60) TRPV3
SCHEMBL5650095 0.77 SCN9A (0.46) TRPV3SCN9AKIF11
SCHEMBL13680818 0.77 TRPV3 (0.52) TRPV3SCN9ACHRNA7
SCHEMBL28345610 0.77 KIF11 (0.65) TRPV3SCN9AKIF11
SCHEMBL787618 0.76 SCN9A (0.58) TRPV3SCN9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024026483-A2 CDK2 INHIBITORS AND METHODS OF USING THE SAME CEDILLA THERAPEUTICS, INC. (US) 2024-02-01 WO disclosed
US-7338960-B2 Phenylalkanoic acid and phenyloxyalkanoic acid derivatives as hPPAR activators SMITHKLINE BEECHAM CORPORATION (US) 2008-03-04 US disclosed
EP-1513526-B1 PHENYLALKANOIC ACID AND PHENYLOXYALKANOIC ACID DERIVATIVES AS HPPAR ACTIVATORS SMITHKLINE BEECHAM CORP (US) 2007-11-07 EP disclosed
US-20060089394-A1 Phenylalkanoic acid and phenyloxyalkanoic acid derivatives as hppar activators SMITHKLINE BEECHAM CORPORATION 2006-04-27 US disclosed
CN-1674897-A Phenylalkanoic acid and phenyloxyalkanoic acid derivatives as HPPAR activators SMITHKLINE BEECHAM CORP (US) 2005-09-28 CN disclosed
EP-1513526-A1 PHENYLALKANOIC ACID AND PHENYLOXYALKANOIC ACID DERIVATIVES AS HPPAR ACTIVATORS SMITHKLINE BEECHAM CORPORATION (US) 2005-03-16 EP disclosed
WO-2004000315-A1 PHENYLALKANOIC ACID AND PHENYLOXYALKANOIC ACID DERIVATIVES AS HPPAR ACTIVATORS SMITHKLINE BEECHAM CORPORATION (US) 2003-12-31 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060089394-A1 Phenylalkanoic acid and phenyloxyalkanoic acid derivatives as hppar activators LIPA, PNLIP, CEL TRPV3 334/4885SCN9A 708/4885KIF11 1492/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.