Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 2/20 | 0.43 |
| ▸ | CCND3 | P30281 | 2/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | CCND2 | P30279 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 3/20 | 0.40 |
| ▸ | JAK3 | P52333 | 5/20 | 0.39 |
| ▸ | JAK2 | O60674 | 4/20 | 0.39 |
| ▸ | JAK1 | P23458 | 3/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.39 |
| ▸ | PIM1 | P11309 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | FLT3 | P36888 | 2/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | CDK9 | P50750 | 2/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.39 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.39 |
| ▸ | MELK | Q14680 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3713882 | 0.86 | CDK4 (0.48) | CDK4CCND3CCND1CCND2JAK3 | |
| SCHEMBL15163200 | 0.86 | CDK4 (0.46) | CDK4CCND3CCND1CCND2JAK3 | |
| SCHEMBL3721153 | 0.86 | CDK4 (0.43) | CDK4CCND3CCND1CCND2SYK | |
| SCHEMBL15163102 | 0.83 | TBK1 (0.44) | CDK4CCND3CCND1CCND2CNR2 | |
| SCHEMBL1285231 | 0.81 | TBK1 (0.58) | MELKSTK17ATYK2 | |
| SCHEMBL3790797 | 0.80 | XDH (0.35) | XDH | |
| SCHEMBL15163477 | 0.80 | CDK4 (0.53) | CDK4CCND3CCND1CCND2SYK | |
| SCHEMBL1285233 | 0.76 | CDK4 (0.38) | CDK4CCND3CCND1CCND2SYK | |
| SCHEMBL15163234 | 0.74 | SYK (0.47) | CDK4SYKJAK3JAK2JAK1 | |
| SCHEMBL3713884 | 0.71 | CDK4 (0.48) | CDK4CCND3CCND1CCND2SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403853-B1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RES COUNCIL TECHNOLOGY (GB) | 2013-08-14 | — | — | EP | claimed |
| WO-2010100431-A1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2010-09-10 | — | — | WO | claimed |
| EP-2403853-B1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RES COUNCIL TECHNOLOGY (GB) | 2013-08-14 | — | — | EP | disclosed |