Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3790800 | 0.86 | KDM1A (0.36) | XDHMAP4K4HTR6L3MBTL1 | |
| SCHEMBL3721151 | 0.80 | CDK4 (0.43) | XDH | |
| SCHEMBL3721153 | 0.65 | CDK4 (0.43) | — | |
| SCHEMBL15163200 | 0.65 | CDK4 (0.46) | — | |
| SCHEMBL3713882 | 0.65 | CDK4 (0.48) | — | |
| SCHEMBL15163102 | 0.64 | TBK1 (0.44) | — | |
| SCHEMBL3713447 | 0.58 | LRRK2 (0.38) | — | |
| SCHEMBL15163477 | 0.58 | CDK4 (0.53) | MAP4K4 | |
| SCHEMBL16035364 | 0.58 | ALDH1A1 (0.43) | XDH | |
| SCHEMBL3715751 | 0.57 | LMNA (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100431-A1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2010-09-10 | — | — | WO | disclosed |